Prolotherapy in the Treatment of Knee Osteoarthritis: How to Perform

Abstract The conservative treatment of knee osteoarthritis is a challenge; since it has no cure, many patients do not want or cannot undergo surgical procedures. Among the various options, we have injectable therapies, especially the so‐called “regenerative,” such as the use of hyaluronic acid, orthobiologicals, and prolotherapy. In the latter, its use has increased, either due to ease of application, low cost, or good results, especially with the improvement of pain and function. This technical note describes the protocol for the preparation and injection of intra‐ and extra‐articular prolotherapy in the treatment of knee osteoarthritis. Numerous articles show its benefit both in improving the symptomatic picture and the life quality of affected patients, as long as we follow ideal parameters of the preparation of the substance and how to apply it.