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in ROS generation in A549 cells, induced mitochondrial dysfunction as evidenced by JC-1 staining, induced lactate dehydrogenase release in medium, inhibited DNA synthesis and triggered apoptosis. DNA-binding studies, supported by molecular docking calculations, showed strong affinity of the compounds for double stranded DNA, to which they bind by intercalation.
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Felix Bacher
University of Vienna
Christian Madejski
University of Vienna
Irina Kuznetcova
University of Vienna
European Journal of Medicinal Chemistry
National Institutes of Health
National Cancer Institute
University of Vienna
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Bacher et al. (Tue,) studied this question.
synapsesocial.com/papers/6a170bc5f96f07bf256b892f — DOI: https://doi.org/10.1016/j.ejmech.2026.118882