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May 28, 2026Regulatory Toxicology and Pharmacology1 citationsOpen Access

Genotoxicity of 4,4’-methylenedianiline in the context of liver damage in rodents

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UEUnterberger-Henig ElifRBRobert A. BudinskyBDBilly W. Day

Key Points

  • This research aims to evaluate the genotoxic effects of 4,4'-methylenedianiline in the context of liver damage in rodents.
  • Administered 4,4'-methylenedianiline to rodents at varying doses including those causing liver damage.
  • Assessed genotoxic effects through analysis of chromosomal damage and tumor formation.
  • Observed liver tumors in rodents exposed to 4,4'-methylenedianiline.
  • No genotoxic effects were found at non-hepatotoxic dose levels.
  • Chromosomal damage occurred only at levels causing significant liver toxicity.

Abstract

• 4,4’-Methylenedianiline induces liver tumors in rodents. • A genotoxic mode of action is not supported by the presented data. • Chromosomal damage occurs only at overtly hepatotoxic dose levels. • Sustained liver damage triggers cytotoxic-regenerative proliferation. • This is consistent with a non-genotoxic mode of action.

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Cite This Study

Elif et al. (2026) studied this question.

synapsesocial.com/papers/6a17daca3fad632b0f9d7bb5https://doi.org/10.1016/j.yrtph.2026.106137
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