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May 28, 2026Poultry ScienceOpen Access

Insights into the Therapeutic Potential of Silymarin-encapsulated CME@ZIF-8 Against CCl4-induced Toxicity in Broiler Chicks

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Authors

ZJZhang JiabinMAMohammed Al-RasheedARAbdur Rauf

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Overview

Randomized trial examines Sil@CME@ZIF-8 effectiveness against CCl4 toxicity in broiler chicks, indicating promising veterinary applications.

Key Points

  • This study aims to evaluate the protective efficacy of silymarin-encapsulated CME@ZIF-8 against CCl4-induced toxicity in broiler chicks.
  • Broiler chicks were induced with CCl4 toxicity and treated with CME@ZIF-8 nanocomposites containing silymarin (5, 10, and 15 mg/kg).
  • Evaluated organ weights, oxidative stress biomarkers (TBARS, ROS), antioxidant enzyme activities (CAT, POD, SOD), histopathological changes, and genotoxicity via comet assay.
  • Results compared pre- and post-treatment outcomes to assess protective effects.
  • CCl4 treatment caused significant weight loss in visceral organs and increased oxidative stress biomarkers (p<0.05).
  • Sil@CME@ZIF-8 treatment improved organ weight and oxidative biomarkers in a dose-dependent manner (p<0.01).
  • Histopathological evaluation indicated reduced necrosis and DNA fragmentation compared to CCl4-only treated groups.

Cite This Study

Jiabin et al. (2026) studied this question.

synapsesocial.com/papers/6a17daf83fad632b0f9d7cfbhttps://doi.org/10.1016/j.psj.2026.107176
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