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May 28, 2026ACS CatalysisOpen Access

Asymmetric Iron-Catalyzed Multicomponent Radical Dicarbofunctionalization of Vinyl Organoboron Compounds

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Authors

AGAchyut R. GogoiPMPoulami MukherjeeBSBen Sinclair

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Overview

Randomized trial demonstrates high stereoselectivity in vinyl organoboron compounds, suggesting new methods for chemical synthesis.

Key Points

  • This work aims to develop iron-catalyzed methodologies for asymmetric radical dicarbofunctionalization using vinyl boronate esters.
  • Employing inexpensive iron salts with chiral bisoxazoline or amide ligands
  • Utilizing mechanistic investigations including 57Fe Mössbauer spectroscopy and single-crystal X-ray analysis
  • Assessing the reaction outcomes for enantioenriched alkyl boron compounds.
  • Achieved enantioenriched alkyl boron compounds with stereoselectivity up to 99:1 e.r.
  • Revealed a catalytic cycle featuring chiral bis- and mono-aryl iron (II) (BOX) species
  • Provided insights into design principles for enantioselective catalysis with earth-abundant metals.

Cite This Study

Gogoi et al. (2026) studied this question.

synapsesocial.com/papers/6a17dc233fad632b0f9d8dfbhttps://doi.org/10.1021/acscatal.6c01837
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