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May 28, 2026Food & Function0 citations

Diphlorethohydroxycarmalol isolated from Ishige okamurae improves age-related muscle dysfunction by Ca 2+ -dependent response via the SirT1/PGC-1α pathway in vitro and in vivo

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XWXueyu WangCKChan-Young KimJJJun-Geon Je

Key Points

  • This research investigates the effects of diphlorethohydroxycarmalol on age-related muscle dysfunction through specific molecular pathways.
  • Isolated diphlorethohydroxycarmalol from Ishige okamurae.
  • Assessed Ca2+ release from the sarcoplasmic reticulum and activation of the AMPK/SirT1/PGC-1α signaling pathway.
  • Evaluated reactive oxygen species production in vitro and in vivo.
  • Diphlorethohydroxycarmalol significantly stimulates Ca2+ release, improving muscle function.
  • Activation of the AMPK/SirT1/PGC-1α pathway reduces ROS production.
  • Findings indicate a protective effect against age-related muscle dysfunction.

Abstract

DPHC from brown algae Ishige okamurae stimulates the release of Ca 2+ from the sarcoplasmic reticulum, activates the AMPK/SirT1/PGC-1α signaling pathway, and reduces ROS production, thereby resisting age-related muscle dysfunction.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a17dcbb3fad632b0f9d963chttps://doi.org/10.1039/d5fo05213k
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