Serum HMGB1 and sCD14 levels in neonates with jaundice: associations with disease severity and phototherapy efficacy

OBJECTIVE: To investigate the associations of serum high-mobility group box-1 (HMGB1) and soluble cluster of differentiation antigen-14 (sCD14) with disease severity in neonatal jaundice, and to explore their relationship with phototherapy response. METHODS: = 51). Correlations were assessed by Spearman's rank test. Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses were performed. RESULTS: < 0.05). ROC analysis revealed AUCs of 0.75 for HMGB1 alone and 0.75 for sCD14 alone, with their combination yielding a significantly higher AUC of 0.83. CONCLUSIONS: In term neonates with non-hemolytic jaundice without severe comorbidities, serum HMGB1 and sCD14 levels are closely associated with disease severity and correlate with the efficacy of phototherapy. Their combined assessment may provide valuable reference indices for predicting phototherapy outcomes.