ABSTRACT Background Hospital-at-Home (HaH) is increasingly used to manage acute conditions like influenza, but data on long-term outcomes remain limited. Objective To identify clinical predictors of 30- and 90-day adverse outcomes among influenza patients treated at HaH. Methods We retrospectively analyzed 270 adult patients with laboratory-confirmed influenza managed at HaH over 10 influenza seasons. Outcomes included emergency department (ED) visits, hospital readmissions, and all-cause mortality at 30 and 90 days. Results At 30 days, 12.4% had ED visits, 5.1% were readmitted, and 3.4% died; at 90 days, these increased to 16.2%, 6.5%, and 6.8%, respectively. Multivariable analysis identified reduced glomerular filtration rate (GFR < 60 mL/min/1.73m²) at discharge and early ED visits as independent predictors of poor outcomes. Conclusions Renal impairment and early post-discharge ED use are significant predictors of adverse outcomes in influenza patients managed through HaH. These findings help clinicians optimize risk stratification and follow-up strategies during seasonal influenza peaks.
Bazán et al. (Fri,) studied this question.