Dietary polyphenols as modulators of the microbiota–gut–brain axis in depression and anxiety: a preclinical perspective

Key Points

• The research aims to explore how dietary polyphenols influence the microbiota-gut-brain axis in the context of depression and anxiety.
• Examined the effects of dietary polyphenols on gut microbiota composition
• Assessed changes in short-chain fatty acids production and inflammation levels
• Evaluated gut barrier integrity and neurotransmission changes
• Dietary polyphenols significantly increased levels of short-chain fatty acids in the gut
• Reduced neuroinflammation was observed with polyphenol intervention
• Improved neurotransmission and behavioral outcomes were noted in the preclinical model