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May 29, 2026The Journal of Pediatrics0 citationsOpen Access

Mitigating Glycemic Disparities: Understanding Contributions of Sociodemographic Variables in the 4T Study

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AAAnanta AddalaVRVictor RitterBSBlake Shaw

Key Points

  • The study aims to evaluate if early continuous glucose monitoring improves glycemia and reduces disparities in youth with type 1 diabetes.
  • Participants received continuous glucose monitoring within a month of diagnosis.
  • HbA1c was evaluated across sociodemographic factors including race, insurance, and deprivation.
  • Three cohorts were analyzed: historical, pilot, and study 1.
  • At 12 months, HbA1c was 6.5% for non-Hispanic White youth and 6.5% for those with low deprivation.
  • Disparities in HbA1c decreased, with improvements seen in ethnicity and insurance slopes in study 1.
  • Deprivation accounted for 41.3% of HbA1c variability, while race and ethnicity contributed 32.2%.

Abstract

OBJECTIVE: To assess in youth with type 1 diabetes (T1D) whether initiation of early continuous glucose monitoring (CGM) with programmatic support to address sociodemographic barriers is associated with reduced disparities and improved glycemia. METHODS: CGM was initiated <1 month post-diagnosis with remote monitoring and <7% hemoglobin (Hb) A1c target in youth with new-onset T1D in the Teamwork, Targets, Technology, and Tight Glycemia (4T) program. We evaluated HbA1c stratified by race and ethnicity, insurance, deprivation, and language across 3 cohorts: historical (6/2014-12/2016), pilot (7/2018-6/2020), and study 1 (6/2020-03/2022). RESULTS: At 12 months in study 1, HbA1c was lowest among non-Hispanic White (6.5% 95%CI 6.2,6.9), low deprivation (6.5% 95%CI 6.2,6.9), private insurance (6.6% 95%CI 6.3,7), and English preference (6.7%95%CI 6.4,7). HbA1c disparities were attenuated in study 1: ethnicity slopes changed from historical (0.09 95%CI -0.02,0.20) to pilot (0.14 95%CI -0.04,0.31) to study 1 (0.08 [95%CI -0.07,0.23). Insurance slopes improved from historical (0.20 95%CI 0.09,0.31) to pilot (0.12 95%CI -0.06,0.29) to study 1 (0.0195%CI -0.14,0.16). Deprivation (41.3%) and race and ethnicity (32.2%) contributed most to HbA1c variability. CONCLUSIONS: Study 1 was associated with improved glycemic outcomes and attenuation of some disparities, particularly by insurance and ethnicity, supporting 4T as an effective equity-oriented care model. Deprivation emerged as a key model-derived contributor to variability in HbA1c and may represent an important target to reduce disparities in pediatric T1D glycemia.

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Cite This Study

Addala et al. (2026) studied this question.

synapsesocial.com/papers/6a192c0ffab5b468c441505fhttps://doi.org/10.1016/j.jpeds.2026.115156
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