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This research investigates the causal link between metoclopramide use and pheochromocytoma crisis, aiming for a rigorous assessment.

May 29, 2026Drug Healthcare and Patient Safety0 citationsOpen Access

Metoclopramide And Pheochromocytoma Crisis: Causality Assessment Using Literature And VigiBase Data

Metoclopramide and Risk of Pheochromocytoma Crisis: A Causality Assessment Using Literature and VigiBase Data

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Descriptive analysis evaluates the causal link between metoclopramide and pheochromocytoma crisis, suggesting a need for caution.

This research investigates the causal link between metoclopramide use and pheochromocytoma crisis, aiming for a rigorous assessment.
Descriptive analysis of data from literature and WHO VigiBase pharmacovigilance database conducted on February 13, 2025.
Causality assessment at the individual level using the Naranjo Scale for case reports and at the population level using the Austin Bradford-Hill framework.
A total of 62 de-duplicated cases analyzed from VigiBase and literature.
Of 62 cases, almost all were serious, and 12 resulted in fatalities.
Naranjo assessment classified 18 cases as 13 'probable' and 5 'possible'.
Population-level assessment confirmed a strong causal relationship across all nine Bradford-Hill criteria.

Bahta et al. (2026) studied this question.

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May 29, 2026Drug Healthcare and Patient Safety0 citationsOpen Access

Metoclopramide and Risk of Pheochromocytoma Crisis: A Causality Assessment Using Literature and VigiBase Data

View Full Paper

Ask AI

Bookmark

Authors

Descriptive analysis evaluates the causal link between metoclopramide and pheochromocytoma crisis, suggesting a need for caution.

This research investigates the causal link between metoclopramide use and pheochromocytoma crisis, aiming for a rigorous assessment.
Descriptive analysis of data from literature and WHO VigiBase pharmacovigilance database conducted on February 13, 2025.
Causality assessment at the individual level using the Naranjo Scale for case reports and at the population level using the Austin Bradford-Hill framework.
A total of 62 de-duplicated cases analyzed from VigiBase and literature.
Of 62 cases, almost all were serious, and 12 resulted in fatalities.
Naranjo assessment classified 18 cases as 13 'probable' and 5 'possible'.
Population-level assessment confirmed a strong causal relationship across all nine Bradford-Hill criteria.

Bahta et al. (2026) studied this question.

View Full Paper

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