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May 29, 2026Deep Brain StimulationOpen Access

From nodal- to network-centric, state-based neuromodulation for neuropsychiatric disorders

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Authors

KDKerry DaleyPKPegah KahaliKWKevin Wilkins

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Overview

Review discusses improvements in neuromodulation methods to enhance treatment in neuropsychiatric disorders, indicating a shift towards network-based control strategies.

Key Points

  • The review aims to explore the transition from single-site deep brain stimulation to network-centric, state-based neuromodulation for neuropsychiatric disorders.
  • Examines existing deep brain stimulation techniques and their limitations.
  • Proposes network-based, state-driven control policies in neuromodulation.
  • Identifies and discusses three emerging paradigms for targeting network configurations.
  • Advocates for incorporating continuous, adaptive, and patterned stimulation approaches.
  • Highlights the necessity of multimodal and multi-feature state estimation for effective neuromodulation.
  • Emphasizes the integration of connectomic mapping and electrophysiological data for personalized treatment.

Cite This Study

Daley et al. (2026) studied this question.

synapsesocial.com/papers/6a192cf8fab5b468c4415ca9https://doi.org/10.1016/j.jdbs.2026.05.002
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