Access to indole-3-urea/carbamates derivatives via rhodiumcatalysed Lossen rearrangement: a uniform and safe protocol

Key Points

• The aim is to establish a safe and efficient protocol for synthesizing indole-3-urea/carbamate derivatives using rhodium-catalysed Lossen rearrangement.
• Utilized rhodium-catalysed Lossen rearrangement for synthesizing derivatives.
• Evaluated the scability and safety of the synthetic pathway.
• Examined the use of indolyl isocyanates as a substrate.
• Successfully synthesized various indole-3-urea/carbamate derivatives efficiently.
• Demonstrated consistent yields and high purity of the products.
• Established a safe and reproducible protocol for further application in drug discovery.