Bullous Systemic Lupus Erythematosus: Clinical Presentation in Two Asian Cases

Bullous systemic lupus erythematosus (BSLE) is a rare subset of systemic lupus erythematosus (SLE), characterized by the rapid onset of vesiculobullous lesions that primarily affect sun‐exposed areas of the body. These lesions typically form along the dermal–epidermal junction and are associated with the presence of autoantibodies that target the skin. While BSLE often occurs in patients with a prior diagnosis of SLE, it can occasionally present as the initial manifestation of the disease. The diagnosis of BSLE requires a thorough evaluation based on clinical features, immunofluorescence studies, histological findings, and serological testing to distinguish it from other similar dermatological conditions. Herein, we report two cases of BSLE at a tertiary Dermatology Hospital in Vietnam.