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May 29, 2026Phytomedicine0 citationsOpen Access

Amorfrutin-A, a membrane-targeting phytochemical active against multidrug-resistant Staphylococcus aureus: in vitro and in vivo activity and mechanism of action

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MLMassimiliano LucidiFIFrancesco ImperiMTMargherita Turi

Key Points

  • This research aims to evaluate the efficacy and mechanism of action of Amorfrutin-A against multidrug-resistant Staphylococcus aureus.
  • In vitro assays to assess bacteriolysis and membrane disruption by Amorfrutin-A
  • Evaluation of Amorfrutin-A's ability to eradicate biofilms and kill persister cells
  • Synergy testing with standard anti-staphylococcal antibiotics
  • Amorfrutin-A effectively disrupts the staphylococcal membrane, leading to rapid bacteriolysis.
  • It successfully eradicates biofilms formed by Staphylococcus aureus and kills persister cells.
  • Amorfrutin-A shows synergy with standard antibiotics, enhancing their effectiveness.

Abstract

• Amorfrutins are prenylated benzoic acid-based phytochemicals. • Amorfrutin-A (AMF-A) is a powerful anti-staphylococcal agent devoid of cytotoxicity. • AMF-A disrupts the staphylococcal membrane, leading to rapid bacteriolysis. • AMF-A eradicates Staphylococcus aureus biofilms and kills persister cells. • AMF-A synergizes with standard-of-care anti-staphylococcal antibiotics.

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Cite This Study

Lucidi et al. (2026) studied this question.

synapsesocial.com/papers/6a192d65fab5b468c44163ffhttps://doi.org/10.1016/j.phymed.2026.158347
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