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May 29, 2026Journal of Clinical Oncology

Proactive response initiative for symptom management (PRISM): A multi-institutional symptom monitoring program for veterans receiving systemic cancer therapy.

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Authors

DCDenaly ChenSTStephen TullLBLakedia Banks

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Overview

Randomized trial tests a proactive symptom management program for veterans, showing feasibility and high engagement rates.

Key Points

  • The primary aim is to improve early identification and treatment of cancer-related symptoms in veterans receiving systemic therapy.
  • Multi-institutional, technology-enabled clinical program tailored for veterans receiving cancer treatment.
  • Weekly telephone assessments conducted by peer specialists using a modified Veteran Symptom Assessment System (VSAS).
  • Nurse Practitioner reviews triggered by symptom scores ≥4 or a 2-point increase on the VSAS scale.
  • 30 veterans enrolled from May to December 2025; 13% withdrew within 1 month, and 6.7% completed the program.
  • Fatigue was most commonly reported (61%), with significant early intervention engagement by Nurse Practitioners in 91% of encounters.
  • A total of 961 interventions recorded, primarily focused on patient education (86%) and medication prescriptions (13%).

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a192da0fab5b468c4416766https://doi.org/10.1200/jco.2026.44.16_suppl.11115
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development and implementation of a digital remote symptom monitoring program (RESPONSe) to support patients undergoing IV chemotherapy at a community ambulatory cancer clinic in Richmond, BC, Canada.2024 · 2 citations
  2. 2ID #631 Promoting Resilience in Stress Management (PRISM): The feasibility of integrating PRISM within a pediatric neuro-oncology population2026
  3. 3Feasibility and proof-of-concept of a combined resilience and social connection intervention for adolescents and young adults with cancer: a pilot randomized trial protocol2026
  4. 4Symptom monitoring program linked to electronic referrals (SyMPLER): A single-arm pilot feasibility study of remote symptom monitoring with palliative care self-referral.2026
  5. 5Trajectory of symptoms reported in remote symptom monitoring over the course of oncology treatment for lung cancer.2024