Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 29, 2026Neural Regeneration ResearchOpen Access

Human induced pluripotent stem cell–derived cortical grafts rebuild motor circuits after brain injury

View Full Paper
Ask AI
Bookmark
Share

Authors

MGMyles D. GladenZLZane R. Lybrand

Discussion

Loading...

Member takes

Overview

Randomized trial demonstrates motor function restoration in mice after brain injury using stem cell grafts, indicating therapeutic potential.

Key Points

  • Investigate if human induced pluripotent stem cell-derived cortical organoids can repair motor deficits and integrate into the adult brain.
  • Cortical organoids generated via modified dual-SMAD inhibition protocol.
  • Transplanted into the motor cortex of NOD-SCID mice after controlled cortical impact.
  • Motor function recovery assessed within 28 days following transplantation.
  • Mice with grafts achieved full recovery of contralateral forelimb motor function within 28 days.
  • Grafts selectively projected to canonical efferent motor pathway targets bilaterally with minimal off-target integration.
  • Identification of synaptic structures indicating integration of graft-derived neuronal inputs into host neurons.

Cite This Study

Gladen et al. (2026) studied this question.

synapsesocial.com/papers/6a192da0fab5b468c44168d7https://doi.org/10.4103/nrr.nrr-d-25-01272
View Full Paper
Ask AI
Bookmark
Share