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May 29, 2026Journal of the American Academy of Orthopaedic Surgeons0 citations

Opioids And Gabapentinoids After Total Joint Arthroplasty: Overdose Risks

Risk of Overdose and Adverse Events With Concomitant Opioids and Gabapentinoid Use After Total Joint Arthroplasty

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Authors

PDPaolo Tristian DomingoGBGarrett K. BergerPGPatricia Gray

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Overview

Retrospective cohort study compares opioid overdose and adverse events with opioid and gabapentinoid combinations after total joint arthroplasty, suggesting no significant differences.

Key Points

  • The aim was to evaluate safety outcomes of opioids alone versus opioids plus low-dose gabapentinoids in opioid-naïve patients post-total joint arthroplasty.
  • Multicenter, population-based, retrospective cohort study within a health system
  • Included opioid and gabapentinoid-naïve patients undergoing total joint arthroplasty from 2018 to 2024
  • Patients were grouped based on prescription after surgery—opioids alone or opioids plus gabapentinoids.
  • Total cohort included 36,351 patients, with 29,009 in the opioids-alone group and 7,342 in the combined group.
  • There were 19 opioid-related overdose events (0.05%), with 14 in the opioids-alone group and 5 in the combined group (P=0.3).
  • 233 patients (0.6%) had emergency department admissions due to adverse events; 200 from the opioids-alone group and 33 from the combined group, showing no significant difference.

Cite This Study

Domingo et al. (2026) studied this question.

synapsesocial.com/papers/6a192df7fab5b468c4416f78https://doi.org/10.5435/jaaos-d-25-01651
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