Background: Hirschsprung’s disease is a developmental disorder characterized by the absence of ganglia in the distal colon. It is one of the common surgical causes of intestinal obstruction in neonates with incidence of 1 in 1500 live births. This condition requires multidisciplinary care including neonatal and surgical expertise for better outcome.Aims and objectives: To describe the clinical profile, complications and outcomes in neonates with Hirschsprung's disease.Methods: This was a retrospective observational study of neonates with biopsy proven Hirschsprung’s disease admitted in NICU between Jan 2018 to June 2022. The data was collected from hospital records, tabulated, and analyzed using standard statistical analysis.Results: A total of 43 Neonates with Hirschsprung’s disease were included in the study. Majority were term neonates (86%) with increased male preponderance. Age of presentation being 2nd-5th day. 12% were low birth weight, 20% had sepsis. 16% had shock, 16% had thrombocytopenia, 9% had MODS, 52% required blood transfusion. 18% had renal failure. 14% had coagulopathy. 2% had wound dehiscence. 2% had wound infection. 16% required mechanical ventilation. 9% had CLABSI. 72% had growth failure at the time of discharge. 25% had associated anomalies. Mortality rate was found to be 13%.Conclusion: Early identification and transportation of neonates with Hirschsprung diseas may help in decreasing the mortality. Maintenance of infection control is important as there was increase in sepsis in postoperative period. Proper nutrition, early enteral feeding and good post-operative care can improve the outcome.
CS. et al. (Wed,) studied this question.