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May 29, 2026Journal of Clinical Oncology

Patterns of upper endoscopy use prior to gastric cancer diagnosis among high-risk populations.

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Authors

RKRohit KhullarXZXiaocen ZhangSFSonia Friedman

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Overview

Retrospective cohort study describes pre-diagnostic endoscopy patterns in high-risk populations, highlighting care gaps.

Key Points

  • The aim is to evaluate the patterns of upper endoscopy use prior to gastric cancer diagnosis in high-risk populations.
  • Retrospective cohort study using Epic SlicerDicer to identify adults diagnosed with gastric adenocarcinoma.
  • Assessment of upper endoscopy (EGD) performed 6–36 months before diagnosis, excluding procedures within 6 months.
  • Analysis of high-risk features including race, ethnicity, and gastric precursor conditions.
  • 45.7% of patients underwent EGD 6–36 months before diagnosis; most EGDs occurred near cancer diagnosis.
  • Higher EGD rates were found in Hispanic patients (57.7%) compared to non-Hispanic patients (46.2%).
  • Only about half of patients with gastric precursor conditions had prior EGD, indicating significant gaps in preventive evaluation.

Cite This Study

Khullar et al. (2026) studied this question.

synapsesocial.com/papers/6a192e39fab5b468c44172ddhttps://doi.org/10.1200/jco.2026.44.16_suppl.11192
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between pre-diagnostic upper endoscopy and metastatic gastric cancer at diagnosis among patients from high-risk groups.2026
  2. 2Abstract 4794: Impact of prior upper endoscopy on gastric cancer stage and survival2024
  3. 3Impact of Prior Upper Endoscopy on Gastric Cancer Stage and Survival in Older Adults2025 · 2 citations
  4. 4The Full Scope: Standardization of the Use of Endoscopy for Earlier Diagnosis of Stomach Cancer in the USA2026 · 1 citations
  5. 5Single-Time Gastroscopy in High-Risk Patients: Screening Effectiveness for Gastric Precancerous Conditions in a Low-To Moderate-Incidence Population2025 · 1 citations