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May 29, 2026Arabian Journal of Chemistry0 citationsOpen Access

Duplex Detection of AAA Biomarkers Using Palladium Nanocube-Modified Electrodes

Analyzing duplex formation with abdominal aortic aneurysm biomarker on palladium nanocube attached interdigitated electrodes

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Authors

GLGuojian LiJCJ ChenXGXi Guo

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Overview

Randomized trial analyzes biomarker detection for AAA diagnosis using a novel sensor technology, indicating enhanced specificity.

Key Points

  • The study aims to develop a sensor method for detecting AAA biomarkers IGF1 and IGFBP1 using palladium nanocube-modified electrodes.
  • Developed a duplex detection method on interdigitated electrodes modified with palladium nanocubes.
  • Utilized anti-IGFBP1 monoclonal antibody and anti-IGF1 aptamer for specific binding.
  • Conducted tests with spiked serum samples to verify detection specificity.
  • Detected IGF1 and IGFBP1 at concentrations as low as 10 fg/mL and 10 pg/mL respectively.
  • Achieved strong linear regression (R2 values of 0.9975 for IGF1 and 0.9953 for IGFBP1).
  • Confirmed specific detection without interference from closely related biomarkers.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a192e79fab5b468c44178achttps://doi.org/10.25259/ajc_1097_2025
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Also Consider

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  1. 1High‐performance detection of an abdominal aortic aneurysm biomarker by immunosensing2019 · 14 citations
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  3. 3Identification and Validation of Plasma Protein Biomarkers for Abdominal Aortic Aneurysm Using Integrated Proteomics2026
  4. 4Biomarkers And Screening Tests For Abdominal Aortic Aneurysm: A Brief Review2009 · 1 citations
  5. 5Abdominal Aortic Aneurysm Detection in Bioelectrical Impedance Cardiovascular Screenings—A Pilot Study2023