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This study aims to assess cumulative pregnancy and live birth rates, along with perinatal and obstetric outcomes, in POSEIDON patients undergoing ART.

May 29, 2026Archives of Gynecology and Obstetrics0 citationsOpen Access

Cumulative pregnancy and cumulative live birth rates and perinatal and obstetric outcomes in POSEIDON patients: insights from 19,371 IVF/ICSI cycles

DWDi Wu WLWanwan Luo HLHui Li

Key Points

This study aims to assess cumulative pregnancy and live birth rates, along with perinatal and obstetric outcomes, in POSEIDON patients undergoing ART.
Enrolled 19,371 patients undergoing first IVF/ICSI cycles from January 2016 to December 2021.
Divided participants into 4 Poseidon subgroups and a non-Poseidon group based on ovarian reserve and response.
Analyzed pregnancy rate, live birth rate, and perinatal outcomes across these subgroups.
Cumulative pregnancy rates decreased from 84.6% in non-PG patients to 30.7% in PG4 patients (p < 0.001).
Cumulative live birth rates ranged from 81.0% in non-PG to 22.9% in PG4 patients (p < 0.001).
PG patients showed decreased gestational age and birth weight, with increased rates of preterm births and cesarean sections.

Abstract

PURPOSE: The objective of this study was to investigate the cumulative pregnancy, cumulative live birth, and perinatal and obstetric outcomes of individuals in the POSEIDON group, with the aim of enhancing the management of individuals receiving assisted reproductive technology (ART) who have characteristics associated with a poor prognosis. METHODS: In this study, 19,371 patients with infertility who underwent their first IVF/ICSI cycle at the Tongji Hospital from January 2016 to December 2021 were enrolled. The population was divided into 4 Poseidon subgroups (PG1-PG4) and a non-Poseidon (non-PG) group based on the POSEIDON criteria. The stratification is based on ovarian reserve and ovarian response to stimulation, with the goal of tailoring individualized stimulation strategies. RESULTS: The cumulative clinical pregnancy rate (CPR) gradually decreased from non-PG patients to PG 1-4 patients, with rates of 84.6%, 72.5%, 54.7%, 51.7%, and 30.7%, respectively. The cumulative live-birth rate (CLBR) was highest in non-PG patients, followed by PG1 patients, PG3 patients, PG2 patients, and PG4 patients, with rates of 81.0%, 67.0%, 45.3%, 45.2%, and 22.9%, respectively (p 50%) and were not associated with an increased risk of abnormal perinatal outcomes.

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