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May 29, 2026Journal of Perinatology0 citationsOpen Access

Delivery room resuscitation of conjoined twins

KWK. Taylor WildNRNatalie E. RintoulAAAnne M. Ades

Key Points

  • This study aims to describe the delivery room resuscitation efforts and hospital outcomes for conjoined twins.
  • Retrospective single-center study of conjoined twins from 2013 to 2025.
  • Main outcomes included characteristics of delivery room interventions.
  • Secondary outcomes focused on survival rates and length of hospital stay.
  • Out of 19 sets of conjoined twins, active resuscitation was performed in 13 and palliative care in 6.
  • Respiratory interventions required included 75% continuous positive airway pressure, 67% positive pressure ventilation, and 25% endotracheal intubation.
  • Among the 10 sets that underwent separation, survival rates at NICU discharge were 80% for twin A and 100% for twin B.

Abstract

Abstract Objective Describe the golden hour and hospital outcomes of conjoined twins Methods Retrospective single center study of conjoined twins. Main outcome measures included delivery room characteristics. Secondary outcomes included survival and length of stay. Results From 2013-2025, there were 19 sets of conjoined twins (active resuscitation in 13; palliative in 6). Respiratory interventions in the delivery room were frequently needed including continuous positive airway pressure (75%), positive pressure ventilation (67%), and endotracheal intubation (25%). There were two sets with emergency separation, each with one surviving twin. For the 10 sets who underwent separation, survival at NICU discharge was 80% (twin A) and 100% (twin B). Conclusion The delivery room resuscitation of conjoined twins is complex with high rates of advanced respiratory intervention. These deliveries necessitate an experienced multidisciplinary team and an individualized delivery plan based on specific anatomy and reinforced with simulation. Survival is high among twins who undergo separation.

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Cite This Study

Wild et al. (2026) studied this question.

synapsesocial.com/papers/6a192e95fab5b468c4417b01https://doi.org/10.1038/s41372-026-02735-5
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