Neoadjuvant and adjuvant (neoadj-adj) enfortumab vedotin (EV) plus pembrolizumab (pembro) in participants with cisplatin-ineligible muscle-invasive bladder cancer (MIBC): An analysis of clinically relevant subgroups in KEYNOTE-905.
Randomized trial shows enhanced survival in muscle-invasive bladder cancer with combined therapy, suggesting effective treatment options.
Key Points
This study aims to analyze the efficacy of neoadjuvant and adjuvant enfortumab vedotin with pembrolizumab in specific subgroups of muscle-invasive bladder cancer patients.
Patients with cisplatin-ineligible muscle-invasive bladder cancer were randomly assigned to receive either enfortumab vedotin plus pembrolizumab and radical cystectomy with pelvic lymph node dissection or control treatment.
Event-free survival, overall survival, and pathological complete response rates were analyzed in various clinical subgroups.
The study involved a total of 344 patients.
Event-free survival in T2N0 patients was not reached for both groups, with HR 0.26; 95% CI 0.08-0.80.
In T3-T4aN0 patients, median event-free survival was not reached for EV + pembro versus 17.2 months for control (HR 0.43; 95% CI 0.29-0.63).
Pathological complete response rate was significantly higher in EV + pembro group—57.1% vs 6.8% in T3-T4aN0 group.