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May 29, 2026Journal of Orthopaedic Trauma

Single Antibiotic Use with Ceftriaxone for Prophylaxis of All Open Fractures

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Authors

MKMichael W. KoulopoulosABAlison BuseckCLConor P. Lynch

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Overview

Retrospective cohort study compares ceftriaxone outcomes for open fractures, indicating effective prophylaxis.

Key Points

  • The aim was to compare the effectiveness of ceftriaxone versus cefazolin-based protocols for preventing infections in open fractures.
  • Retrospective cohort study including adult patients with open fractures from December 2016 to December 2022.
  • Comparison of deep infection, superficial infection, nonunion, and time to antibiotic administration between two treatment groups (CTX and Classic).
  • Data analysis involved patient outcomes based on Gustilo fracture types.
  • Deep infection rates for ceftriaxone were 7.8% compared to 12.7% for cefazolin, p=0.095, demonstrating non-inferiority for all Gustilo types.
  • The CTX protocol showed a significantly shorter time to antibiotic administration (63.9 minutes vs 114.1 minutes, p=0.002).
  • No significant differences in rates of superficial infection or nonunion were observed.

Cite This Study

Koulopoulos et al. (2026) studied this question.

synapsesocial.com/papers/6a192ee7fab5b468c441837ehttps://doi.org/10.1097/bot.0000000000003229
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