A Retrospective Cohort Study Assessing the Prognostic Significance of Tumor-Associated Macrophages (TAMs) in Gastric Cancer in the Indian Population.

Key Points

• This study aims to assess the prognostic significance of tumor-associated macrophages in gastric cancer specifically in the Indian population.
• Retrospective analysis of 60 surgically resected gastric adenocarcinomas.
• CD68 immunohistochemistry used to quantify TAM density.
• Statistical analysis involved chi-square and logistic regression.
• High TAM density found in 70% of cases, associated with larger tumor size (p = 0.05).
• Increased tumor-infiltrating lymphocytes correlated with high TAM density (p = 0.021).
• Lymph node metastasis emerged as an independent predictor of high TAM density (adjusted OR = 2.5; 95% CI: 1.02-6.2; p = 0.04).