Factors associated with clinical outcomes of breast cancer based on glucose metabolic activity of subcutaneous adipose tissue

Background: Obesity increases the risk of breast cancer, with dysfunctional metabolic activity in subcutaneous adipose tissue (SAT) implicated as a key underlying mechanism. This study sought to explore the correlation between SAT metabolic activity and clinical prognosis among patients with breast cancer. Methods: Body composition parameters at the level of the third lumbar vertebra and clinicopathological data from 74 patients with breast cancer were collected. Two Cox models were established using the least absolute shrinkage and selection operator (LASSO) for variable selection. The two models were compared using the time-dependent area under the receiver operating characteristic curve (AUC) and the net reclassification index (NRI). Furthermore, the confounding effects on the association among the mean standard uptake value of subcutaneous adipose tissue (SUVmeanSAT), American Joint Committee on Cancer (AJCC) stage, and progression status in patients with breast cancer were assessed. Results: = 0. 001) were significant independent prognostic factors. The AUC value and NRI of the combined Cox model (SUVmeanSAT plus AJCC stage) were higher than those of the Cox model based on AJCC stage alone. In addition, changes in the effect estimates showed a 12. 2% decrease in hazard ratios when SUVmeanSAT was added to the AJCC stage model. High SUVmeanSAT was significantly associated with an increased risk of progression-free survival in patients with breast cancer. Conclusions: A comprehensive assessment incorporating both SUVmeanSAT and AJCC stage may enhance understanding of the impact of adiposity on breast cancer prognosis.