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Objective To quantify the morphology and asymmetry of the levator veli palatini (LVP) muscle in children with craniofacial microsomia (CFM) and explore associations with velopharyngeal insufficiency (VPI). Design Retrospective cohort study. Setting Pediatric tertiary care center. Patients, Participants Twenty children with CFM who underwent clinically indicated head and neck MRI. Main Outcome Measures LVP left-right asymmetry, midline velopharyngeal measures, and presence of VPI. Results Three participants (15%) had VPI. Significant left-right asymmetry was observed for total LVP length, LVP thickness at velar insertion, and angle of origin ( p ≤ .05). Greater differences between most and least affected sides in total LVP length were associated with lower VPI prevalence (PR, 0.58 per 1-mm increase; 95% CI, 0.36–0.93; p = .02). Greater pharyngeal depth predicted higher VPI prevalence (PR, 1.35 per 1-mm increase; 95% CI, 1.07–1.70; p = .01), while increased midline LVP thickness was associated with lower prevalence (PR, 0.76 per 1-mm increase; 95% CI, 0.65–0.90; p = .01). Conclusion Children with CFM demonstrate significant asymmetry of the LVP muscle. Shorter total LVP length, thinner midline LVP, and greater pharyngeal depth were associated with higher VPI prevalence, indicating a need for prospective studies to clarify the role of soft-tissue variation in velopharyngeal function.
Kotlarek et al. (2026) studied this question.