Higher residual SYNTAX score after PCI independently predicted 1-year ischemic outcomes, including all-cause mortality (HR 1.05; 95% CI 1.02-1.09; p=0.006).
Cohort (n=2,686)
Does incomplete revascularization (quantified by residual SYNTAX score) increase adverse ischemic outcomes in patients with moderate- and high-risk ACS undergoing PCI?
Quantifying incomplete revascularization with the residual SYNTAX score demonstrates that an rSS >8.0 after PCI in moderate- to high-risk ACS patients is independently associated with increased 1-year mortality and ischemic events.
Effect estimate: HR 1.05 (95% CI 1.02-1.09)
p-value: p=0.006
Objectives The purpose of this study was to quantify the extent and complexity of residual coronary stenoses following percutaneous coronary intervention (PCI) and to evaluate its impact on adverse ischemic outcomes. Background Incomplete revascularization (IR) after PCI is common, and most studies have suggested that IR is associated with a worse prognosis compared with complete revascularization (CR). However, formal quantification of the extent and complexity of residual atherosclerosis after PCI has not been performed. Methods The baseline Synergy Between PCI With Taxus and Cardiac Surgery (SYNTAX) score (bSS) from 2,686 angiograms from patients with moderate- and high-risk acute coronary syndrome (ACS) undergoing PCI enrolled in the prospective ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial was determined. The SS after PCI was also assessed, generating the “residual” SS (rSS). Patients with rSS >0 were defined as having IR and were stratified by rSS tertiles, and their outcomes were compared to the CR group. Results The bSS was 12.8 ± 6.7, and after PCI the rSS was 5.6 ± 2.2. Following PCI, 1,084 patients (40.4%) had rSS = 0 (CR), 523 (19.5%) had rSS >0 but ≤2, 578 (21.5%) had rSS >2 but ≤8, and 501 patients (18.7%) had rSS >8. Age, insulin-treated diabetes, hypertension, smoking, elevated biomarkers or ST-segment deviation, and lower ejection fraction were more frequent in patients with IR compared with CR. The 30-day and 1-year rates of ischemic events were significantly higher in the IR group compared with the CR group, especially those with high rSS. By multivariable analysis, rSS was a strong independent predictor of all ischemic outcomes at 1 year, including all-cause mortality (hazard ratio: 1.05, 95% confidence interval: 1.02 to 1.09, p = 0.006). Conclusions The rSS is useful to quantify and risk-stratify the degree and complexity of residual stenosis after PCI. Specifically, rSS >8.0 after PCI in patients with moderate- and high-risk ACS is associated with a poor 30-day and 1-year prognosis.
Généreux et al. (2012) conducted a cohort in Moderate- and high-risk acute coronary syndrome (ACS) undergoing PCI (n=2,686). Incomplete revascularization (residual SYNTAX score > 0) vs. Complete revascularization (residual SYNTAX score = 0) was evaluated on All-cause mortality at 1 year (HR 1.05, 95% CI 1.02-1.09, p=0.006). Higher residual SYNTAX score after PCI independently predicted 1-year ischemic outcomes, including all-cause mortality (HR 1.05; 95% CI 1.02-1.09; p=0.006).