The MyoFoldstar sequence enabled rapid and simultaneous myocardial T1 (1521±102 ms), T2 (43.2±3.0 ms), T2* (19.2±2.4 ms), and cine imaging within a single breath-hold scan with good agreement to reference standards.
Does the MyoFoldstar sequence provide accurate simultaneous myocardial T1, T2, T2* mapping and wall-motion quantification compared to conventional single-task sequences in healthy volunteers?
The MyoFoldstar sequence enables rapid and accurate simultaneous myocardial T1, T2, T2*, and cine imaging within a single breath-hold scan, offering a time-saving approach for comprehensive cardiovascular magnetic resonance assessment.
ABSTRACT This study aimed to propose a mixed single‐echo and multiecho MyoFoldstar sequence enabling simultaneous myocardial multiparametric mapping and wall‐motion quantification. MyoFoldstar is designed as a 2D, single breath‐holding sequence that sequentially performs joint T 1 / T 2 mapping, T 2 * mapping, and cine imaging within 17 heartbeats, using a golden‐angle radial gradient‐echo (GRE) readout and ECG synchronization. The joint T 1 / T 2 mapping collects seven single‐shot, single‐echo images on the first seven heartbeats with inversion and T 2 preparation ( T 2 prep). The subsequent T 2 * mapping acquires multishot, multiecho data over six heartbeats, followed by segmented cine with a single‐echo readout over four heartbeats. In vivo feasibility was demonstrated in 12 healthy volunteers at 3 T and compared with conventional single‐task sequences (MOLLI and SASHA for T 1 , T 2 prep bSSFP for T 2 , and BB‐meGRE for T 2 *). Accuracy was validated in phantom studies. Both in vivo and phantom studies demonstrated the feasibility of MyoFoldstar for simultaneously acquiring cardiac T 1 , T 2 , T 2 *, and cine imaging. MyoFoldstar‐derived myocardial T 1 (1521 ± 102 ms), T 2 (43.2 ± 3.0 ms), and T 2 * (19.2 ± 2.4 ms) showed good agreement with values from conventional single‐task sequences ( T 1 : 1248 ± 35 ms by MOLLI and 1580 ± 38 ms by SASHA; T 2 : 43.5 ± 2.2 ms by T 2 prep bSSFP; T 2 *: 23.4 ± 2.6 ms by BB‐meGRE). Compared with conventional cine, MyoFoldstar images exhibited reduced myocardium–blood contrast, yet left ventricular function quantifications were mainly preserved ( r > 0.9). Phantom results indicated that MyoFoldstar achieves good accuracy relative to reference standards. MyoFoldstar enables rapid myocardial T 1 , T 2 , T 2 *, and cine imaging within a single breath‐hold scan, delivering a time‐saving and comprehensive assessment of cardiovascular magnetization resonance.
Guo et al. (2026) studied Healthy volunteers (n=12). MyoFoldstar sequence vs. Conventional single-task sequences (MOLLI, SASHA, T2prep bSSFP, BB-meGRE, conventional cine) was evaluated on Feasibility and accuracy of simultaneous myocardial T1, T2, T2*, and cine imaging. The MyoFoldstar sequence enabled rapid and simultaneous myocardial T1 (1521±102 ms), T2 (43.2±3.0 ms), T2* (19.2±2.4 ms), and cine imaging within a single breath-hold scan with good agreement to reference standards.
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