What does this research mean for the field?

A Ru(II)-catalyzed protocol enables the highly regioselective C8-H sulfonamidation of N-aryl and N-alkylisoquinolones using sulfonyl azides under mild conditions to produce pharmaceutically relevant compounds in good to excellent yields. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to develop a method for C8–H sulfonamidation of isoquinolones using Ru(II) catalysts.

May 30, 2026European Journal of Organic Chemistry0 citations

Ru(II)‐Catalyzed Regioselective C8–H Sulfonamidation of Isoquinolones With Sulfonyl Azides

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SKSuruchi Kumari ASAbhishek Kumar Shaw ARAnushka Rastogi

Key Points

This research aims to develop a method for C8–H sulfonamidation of isoquinolones using Ru(II) catalysts.
Ru(II)‐catalyzed sulfonamidation of N‐aryl and N‐alkylisoquinolones
Utilized sulfonyl azides as the sulfonamide source
Performed under mild conditions to achieve high yields
Regioselective transformation achieved with good to excellent yields.
Aryl and polyaromatic sulfonyl azides provided effective results in the reaction.
Access to pharmaceutically relevant C8–sulfonamidated isoquinolones was established.

Abstract

We report a Ru(II)‐catalyzed, directing‐group‐assisted regioselective C8–H sulfonamidation of N ‐aryl and N ‐alkylisoquinolones using sulfonyl azides. The transformation proceeds under mild conditions with excellent regioselectivity. Aryl and polyaromatic sulfonyl azides delivered products in good to excellent yields. This protocol affords access to pharmaceutically relevant C8‐sulfonamidated isoquinolones.

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Ru(II)‐Catalyzed Regioselective C8–H Sulfonamidation of Isoquinolones With Sulfonyl Azides

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