Grand multiparity (≥5 births) was associated with a 7.8-fold higher likelihood of any left ventricular diastolic dysfunction compared to low parity (1-2 births).
Cross-Sectional (n=186)
Does grand multiparity increase the risk of left ventricular diastolic dysfunction in women compared to low parity?
Grand multiparity (≥5 births) is significantly associated with worse left ventricular diastolic function compared to low parity, suggesting parity history should be incorporated into cardiovascular risk assessments for women.
Effect estimate: OR 7.8
Absolute Event Rate: 87.1% vs 46.3%
A BSTRACT Objectives: While numerous studies have investigated the impact of pregnancy on the cardiovascular system, the long-term alterations in heart structure and diastolic function among grand multiparous women remain under-researched, particularly in the context of contemporary guidelines and diagnostic techniques. This study aimed to investigate the alterations in left ventricular (LV) structure and diastolic function in multiparous women using echocardiography. Materials and Methods: Echocardiography was used to evaluate diastolic function and LV remodeling in 186 women with varying parity numbers. We compared echocardiographic parameters between parity groups: low parity (1–2 births) and grand multiparity (≥5 births). Results: In the low parous group, 33 women (35.5%) had Grade 1 LV diastolic dysfunction (DD), and only 10 participants (10.8%) had Grade 2 or 3 DD. In women with grand multiparity, only 12 of them (12.9%) did not have DD, and 23 participants (24.8%) had Grade 2 or 3 DD. Logistic regression analysis indicates that any DD and Grade 2 or 3 DD have the highest percentage in the grand multiparity group, with 7.8 and 2.7 times greater than the low parous group, respectively. Conclusion: Grand multiparity but not low parity significantly deteriorates LV diastolic function according to the present study. Parity information must be evaluated when determining a cardiovascular risk in women. Additional research is necessary to assess the likelihood of progressive DD with each pregnancy and to determine if parity explains the higher risk of diastolic heart failure in women.
Al-Obaidi et al. (Fri,) conducted a cross-sectional in Left ventricular diastolic dysfunction (n=186). Grand multiparity (≥5 births) vs. Low parity (1-2 births) was evaluated on Any left ventricular diastolic dysfunction (OR 7.8). Grand multiparity (≥5 births) was associated with a 7.8-fold higher likelihood of any left ventricular diastolic dysfunction compared to low parity (1-2 births).
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