XPC and global genome nucleotide excision repair are essential for telomere stability after UVC-induced DNA damage in human cells

Key Points

• This research aims to investigate the role of XPC and global genome nucleotide excision repair in maintaining telomere stability after UVC-induced DNA damage.
• Examined repair efficiency of UV photoproducts in XPC and XPA deficient human cells.
• Assessed transcription coupled NER and its inability to compensate for global genome NER at telomeres.
• Analyzed telomere transcript levels following UVC irradiation in NER deficient cells.
• XPC and XPA deficient cells show significantly reduced repair of UV photoproducts at telomeres.
• Transcription coupled NER does not effectively repair telomeres in global genome NER deficient contexts.
• Following UVC irradiation, specific telomere transcripts are upregulated in NER deficient cells.