What question did this study set out to answer?

This study aims to develop an efficient method for synthesizing amide bonds using carboxylic acids and amines.

May 31, 2026Open Access

Bu4NI-Catalyzed Traceless Coupling of Carboxylic acids and Amines

Key Points

This study aims to develop an efficient method for synthesizing amide bonds using carboxylic acids and amines.
Developed a one-pot procedure using TBAI/TBHP as catalysts.
Utilized 1,4-dioxane as a solvent and acyl-activating agent.
Engaged primary and secondary amines for the synthesis of various amides.
Achieved good to excellent yields of amides.
Successfully synthesized valuable amide-containing pharmaceuticals like Moclobemide and Olaparib.

Abstract

A one-pot procedure for amide bond formation has been developed in the presence of TBAI/TBHP. 1,4-Dioxane serves dual roles as both solvent and a traceless acyl-activating agent for the direct coupling of carboxylic acids with primary and secondary amines, affording the corresponding amides with good to excellent yields. Moreover, the versatility of this strategy is also highlighted by the synthesis of pharmaceutically valuable amide bond-containing molecules such as Moclobemide, Trimethobenzamide, Olaparib, Mitapivat.

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Authors

Junjun Feng

China University of Mining and Technology

Yihao Yang

Jiangsu Food and Pharmaceutical Science College

Huayou Hu

Huaiyin Normal University

Journals

Tetrahedron Green Chem

Actions

Institutions

Huaiyin Normal University

Jiangsu Food and Pharmaceutical Science College

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Bu4NI-Catalyzed Traceless Coupling of Carboxylic acids and Amines

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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