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May 31, 2026Open Access

Understanding the Potential Triggers of Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Post-COVID Syndrome

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Authors

ZLZheng Liu

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Overview

Randomized trial investigates mitochondrial dysfunction links to autoantibodies in ME/CFS and post-COVID patients, indicating potential biomarkers.

Key Points

  • This research aims to explore the role of autoantibodies in mitochondrial dysfunction associated with ME/CFS and post-COVID syndrome.
  • Developed a bead-based chromatography purification system for serum-derived immunoglobulin G (IgG).
  • Created a biobank of purified IgGs from healthy controls, ME/CFS, post-COVID ME/CFS, and multiple sclerosis patients.
  • Conducted in vitro studies to analyze the effect of ME/CFS IgGs on mitochondrial structure and cellular metabolism.
  • ME/CFS IgGs induced mitochondrial fragmentation and impaired cellular energetics in vitro.
  • Increased serum FN1 levels and decreased natural antibody production were observed in both ME/CFS and post-COVID patients.
  • Proteomic analysis showed significant changes in immune complexes from ME/CFS patients.

Cite This Study

Zheng Liu (2026) studied this question.

synapsesocial.com/papers/6a1bd0155783ba022b6fbf28https://doi.org/10.25972/opus-44779
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