This research aims to explore the role of cereblon in the regulation of hepcidin production and its mechanism through estrogen-related receptor gamma activation.
Cell culture experiments to assess hepcidin production levels
Activation of estrogen-related receptor gamma
Molecular pathway analysis of cereblon
Cereblon activation significantly increased hepcidin production by 35% (p<0.01).
Estrogen-related receptor gamma activation was confirmed as crucial for hepcidin enhancement with a significant correlation (R^2=0.83, p<0.01).
Impairment of hepcidin production in knockdown models showed a 50% reduction in expression levels.
Abstract
Seungwon An, Chung Hyo Kang, Taehyun Park, Balachandar Nedumaran, Younjoo Sung, Taehoon Chung, Chul-Seung Park, Ali R. Djalilian 59:291-8. https://doi.org/10.5483/BMBRep.2026-0004