Why the study?
The relationship between platelet reactivity measured as PRU and cardiovascular mortality in CAD remains incompletely characterized, particularly regarding potential non-linear associations.
Is there a non-linear association between platelet reactivity (PRU) and cardiovascular mortality in patients with CAD?
Population
1000 patients with angiographically confirmed CAD treated at a tertiary cardiology center in Kazakhstan
Comparison
Varying platelet reactivity levels measured as PRU
Design
Retrospective observational cohort study
Key result
Platelet reactivity (PRU) exhibited a significant U-shaped association with cardiovascular mortality in CAD patients, whereas conventional linear models showed no association (OR ~1.00; p>0.05).
Authors
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Non-linear PRU-CV mortality link in CAD may exist; leaves open whether PRU-guided adjustment improves outcomes.
Cohort (n=1,000)
No
Is there a non-linear association between platelet reactivity (PRU) and cardiovascular mortality in patients with CAD?
Effect estimate: OR ~1.00
p-value: p=> 0.05
A U-shaped relationship exists between platelet reactivity and cardiovascular mortality in CAD patients, indicating that both insufficient and excessive platelet inhibition confer increased risk.
Жангелова et al. (2026) conducted a cohort in Coronary artery disease (n=1,000). Platelet reactivity (PRU) was evaluated on Cardiovascular mortality (OR ~1.00, p=> 0.05). Platelet reactivity (PRU) exhibited a significant U-shaped association with cardiovascular mortality in CAD patients, whereas conventional linear models showed no association (OR ~1.00; p>0.05).