Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 31, 2026Open Access

Association of glomerular hyperfiltration with mortality in stroke: an analysis using pooled individual patient data.

View Full Paper
Ask AI
Bookmark
Share

Authors

PNPhilip S NashGAGareth AmblerJBJonathan G. Best

Discussion

Loading...

Member takes

Overview

Randomized trial explores the connection between glomerular hyperfiltration and mortality in stroke patients, indicating potential health risks.

Key Points

  • To examine the association between glomerular hyperfiltration and mortality outcomes in stroke patients using pooled data from cohort studies.
  • Pooled data from cohort studies of stroke or TIA populations.
  • Cox proportional hazards regression used to assess risk based on hyperfiltration status and eGFR as a continuous variable.
  • Total of 11,175 patients analyzed with 554 identified as having hyperfiltration.
  • Hyperfiltration associated with all-cause death at 147 per 1000 person-years vs 61 for normofiltration (95% CI, 119-180 vs 57-66).
  • Adjusted HR for all-cause death with hyperfiltration was 1.76 (95% CI, 1.46-2.11; P < .001).
  • Adjusted HR for vascular death was 1.68 (95% CI, 1.29-2.17; P < .001).

Cite This Study

Nash et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd1db5783ba022b6fd4d1https://doi.org/10.48620/98129
View Full Paper
Ask AI
Bookmark
Share