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May 31, 2026Open Access

Outcome associations of CSF total tau in suspected non-Alzheimer pathophysiology.

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Authors

NBNils BrielMBMarc BorsiSSSimon J Schreiner

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Overview

Retrospective study identifies CSF total tau as a survival predictor in SNAP patients, suggesting clinical prognostic value.

Key Points

  • The research aims to explore the associations of CSF total tau with survival outcomes in patients classified with suspected non-Alzheimer pathophysiology (SNAP).
  • Conducted a retrospective study of SNAP patients from two tertiary centers between 2019 and 2024.
  • Analyzed CSF biomarker levels (Aβ42, pTau, tTau) and survival data using Kaplan-Meier curves and multivariable Cox hazard models.
  • Defined SNAP patients with specific biomarker constellations and excluded those with prion disease.
  • Patients with SNAP had a median survival of 31 months, shorter compared to Alzheimer's disease (42 months) and shortest for Alzheimer's pathological change with neurodegeneration (16 months).
  • Total tau levels (tTau) performed best in predicting survival, with an area under the curve (AUC) of 0.83 and a cutpoint of ≥ 600 pg/mL.
  • Multivariable Cox modeling showed tTau was independently associated with survival, with a hazard ratio of 6.1-6.8 (p < 0.001).

Cite This Study

Briel et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd21d5783ba022b6fd7fehttps://doi.org/10.48620/98042
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outcome associations of CSF total tau in suspected non-Alzheimer pathophysiology2026
  2. 2Prognostic significance of cerebrospinal fluid tau biomarkers in amyloid-negative A−T + N + neurodegeneration: A retrospective cohort study2026
  3. 3CSF total tau as a proxy of synaptic degeneration2025 · 14 citations
  4. 4Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer’s disease and other neurodegenerative diseases2024 · 30 citations
  5. 5Alzheimer's Disease Cerebrospinal Fluid Biomarkers Predict Survival in Progressive Supranuclear Palsy2026