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May 31, 2026BMC Endocrine DisordersOpen Access

A nomogram for estimating prevalent gallstone risk in patients with type 2 diabetes: development and validation in a multicenter cohort

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Authors

HHHuan-Shan HongDZDa‐Qing ZhuYHYing Huang

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Overview

Randomized trial assesses gallstone risk in type 2 diabetes patients, suggesting a new tool for risk evaluation.

Key Points

  • This study aimed to create and validate a nomogram for estimating gallstone risk in patients with type 2 diabetes.
  • Retrospective multicenter cohort study including 1,762 type 2 diabetes patients.
  • Logistic regression was employed to build the nomogram for ultrasound-detected gallstones.
  • Evaluation of nomogram performance was conducted through ROC analysis, calibration, and decision curve analysis.
  • Six independent risk factors identified: age ≥ 60, longer diabetes duration, elevated HbA1c, FPG, TG, and diabetic peripheral neuropathy.
  • Nomogram demonstrated good discrimination (AUC = 0.82) across training, internal, and external validation cohorts.
  • Calibration curves indicated consistency between predicted and actual risk, confirming clinical applicability.

Cite This Study

Hong et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd2375783ba022b6fda86https://doi.org/10.1186/s12902-026-02335-6
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