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May 31, 2026RSC Chemical BiologyOpen Access

Tipping the balance: synthesis and evaluation of centrinone-based degraders of polo-like kinase 4

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Authors

AKAndrej KovačevićASAleksandar SalimCBCrisalida Borges

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Overview

Randomized trial evaluates centrinone-based degraders impacting PLK4 stabilization and degradation mechanisms, suggesting significant cellular implications.

Key Points

  • This research aims to investigate the synthesis and effects of centrinone-based degraders on polo-like kinase 4 (PLK4).
  • Synthesis of bifunctional degraders using centrinone as a PLK4 inhibitor.
  • Evaluation of cellular profiles to assess stabilization and degradation via a PROTAC mechanism.
  • Analysis of the dependency of these effects on the cellular localization of PLK4.
  • Centrinone-based degraders show distinct patterns of cellular stabilization and degradation of PLK4.
  • Effects of degradation vary significantly based on the localization of PLK4 within the cells.

Cite This Study

Kovačević et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd2675783ba022b6fdd71https://doi.org/10.1039/d5cb00315f
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