Characterisation of the Novel HLA‐DPA1*03:25 Allele by Next Generation Sequencing

Key Points

• This research aims to characterize the HLA-DPA1*03:25 allele using advanced sequencing techniques.
• Utilized next generation sequencing to analyze HLA-DPA1*03:25 allele's structure.
• Focused on a specific nucleotide substitution in codon 96 of exon 3.
• Identified genetic variations at the nucleotide level.
• Characterized HLA-DPA1*03:25 as having a unique single nucleotide substitution.
• Details regarding the effect of this substitution on allele function remain to be explored.