Mechanistic study of inspiratory training in childhood Asthma: Rationale and methods of a pediatric clinical trial

= 38) 6-17-year-olds with asthma and (2) measure small airway disease and inspiratory muscle function in response to 8 weeks of inspiratory training. We will also assess physical fitness, activity levels, and exertional dyspnea. This study will lay the foundation for dose selection and optimal target population of a larger trial. IT could represent a novel therapy to help children with asthma and obesity improve quality of life through reduced exertional symptoms and enhanced activity levels.