Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: a randomized controlled trial

Key Points

• This research investigates the effects of a 12-week self-paced training program combined with melatonin on health markers in multiple sclerosis patients.
• Randomized controlled trial design involving multiple sclerosis patients.
• Participants underwent 12 weeks of self-paced training along with melatonin supplementation.
• Outcomes measured included oxidative stress, inflammation, hyperlipidemia, and body composition.
• Training+melatonin reduced hyperlipidemia more effectively than either intervention alone.
• This combination provided greater anti-inflammatory and antioxidant effects than single interventions.
• Training+melatonin significantly improved body composition compared to training alone.