What question did this study set out to answer?

This research aims to explore the mutational and expressional changes of the CHEK1 gene in breast cancer patients.

June 1, 2026

Mutational and Expressional Deregulation of the CHEK1 Gene in Breast Cancer Patients

Key Points

This research aims to explore the mutational and expressional changes of the CHEK1 gene in breast cancer patients.
Analyzed 200 breast tumors and adjacent healthy tissues using quantitative real-time PCR.
Assessed mRNA levels of the CHEK1 gene to evaluate its expression in tumor versus control tissues.
CHEK1 gene expression is significantly reduced in breast tumors compared to adjacent control tissues (p < 0.0001).
Alterations in CHEK1 are linked to chemotherapy resistance in the studied population.

Abstract

BACKGROUND: Breast cancer burden is increasing day by day. The identification of novel genetic markers based on polymorphism and expression analysis is necessary to reduce the suffering of patients. AIMS: gene was assessed at the mRNA level. METHODS: gene was assessed in 200 breast tumors along with their adjacent uninvolved healthy tissue using quantitative real time (RT) PCR. RESULTS: < 0.0001) in breast tumor tissues as compared to adjacent control tissues. CONCLUSION: gene also plays an important role in chemotherapy resistance response among the Pakistani population.

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