MEN1/menin deficiency suppresses hepatocellular carcinogenesis via disrupting mitophagy-mediated mitochondrial homeostasis

Key Points

• The study aims to investigate how MEN1/menin deficiency affects hepatocellular carcinogenesis through mitochondrial processes.
• Used knockdown techniques to analyze menin deficiency effects.
• Employed TCGA data for cancer genomics analysis.
• Utilized transmission electron microscopy to observe mitochondrial morphology.
• MEN1/menin deficiency led to reduced hepatocellular carcinogenesis.
• Disruption of mitophagy was confirmed by changes in mitochondrial structure.
• Analysis revealed interactions between mitophagy and mitochondrial health.