Randomized trial evaluates anti-Toxoplasma activity of copper nanoparticles in mice, indicating potential as supplementary treatment.
Key Points
This research aims to evaluate the anti-Toxoplasma effects of copper nanoparticles synthesized from Conocarpus erectus L. using both in vitro and in vivo methods.
Copper nanoparticles were synthesized using the aqueous extract of Conocarpus erectus L.
An MTT assay assessed cell viability against Toxoplasma gondii tachyzoites at various concentrations and exposure times.
In vivo tests involved infecting BALB/c mice with Toxoplasma followed by CuNP treatment and comparison with controls.
CuNPs had a particle size of less than 20 nm, with a maximum peak at 315 nm.
The highest mortality rate of Toxoplasma gondii was observed at 160 ppm concentration after 8 hours of CuNP exposure.
Oral administration of CuNPs increased mice survival time and reduced parasitemia compared to the control group.