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June 2, 2026Materials & Design0 citationsOpen Access

A photocrosslinked micelle-hydrogel hybrid loaded with human dental pulp stem cells for cartilage defect repair

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DXDongdong XuZLZongli LiPSPengfei Shan

Key Points

  • This research aims to evaluate the effectiveness of a micelle-hydrogel hybrid for repairing cartilage defects using human dental pulp stem cells.
  • Developed a photocrosslinked micelle-hydrogel hybrid (GMKFM) for cartilage repair.
  • Tested the hybrid for mechanical stability and sustained KGN release.
  • Assessed the chondrogenesis of human dental pulp stem cells (hDPSCs) within the hybrid in vitro.
  • GMKFM demonstrated mechanical stability and supported sustained release of KGN.
  • hDPSCs-laden GMKFM significantly enhanced cartilage repair in a rat model.

Abstract

• A photocrosslinked micelle-hydrogel hybrid (GMKFM) for cartilage defect repair. • GMKFM provides mechanical stability and enables sustained KGN release. • GMKFM supports chondrogenesis of human dental pulp stem cells (hDPSCs). • hDPSCs-laden GMKFM enhances cartilage repair in a rat model.

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a1e72ad30b38c64201b5ec9https://doi.org/10.1016/j.matdes.2026.116303
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