AbstractPurpose To investigate the effects of Lenslet-ARray-Integrated (LARI) spectacle lenses on refractive and corneal astigmatism in myopic children. Design A secondary analysis of data from a randomized, double-masked trial. Participants Pertinent data were retrieved from the files of 209 participants from the previous 2-Phase LARI study, which reported the efficacy of LARI lenses on myopia control in children aged 6 - 12 years. Methods Data from participants of the LARI study (Phase 1: wearing LARI lenses or single-vision (SV) lenses for 12 months; Phase 2: all wore LARI lenses for another 12 months) were retrieved and analysed. Participants who wore LARI lenses for two years were categorized as the LARI group, whereas those who switched from SV to LARI lenses were categorized as the SV-LARI group. Data retrieved included cycloplegic SER and refractive astigmatism, axial length, and corneal astigmatism at 6-month intervals, and the vector components (J0 and J45) of refractive and corneal astigmatism were calculated for analysis. Main Outcome Measures Changes in refractive and corneal astigmatism, J0, and J45. Results No significant differences were found in increased refractive astigmatism, refractive J0 and J45, corneal astigmatism, corneal J0 and J45 (all P > 0.05) between the LARI and SV groups in Phase 1. For participants who wore LARI lenses for two consecutive years, there were no significant differences in changes in refractive astigmatism and refractive J0 between Phases 1 and 2 (P = 0.23 and P = 0.41), but change in J45 in Phase 2 increased by -0.03 D (P = 0.003), and a smaller increase in corneal astigmatism was observed in the second year (0.07 ± 0.36 D vs 0.20 ± 0.34 D, P = 0.02). In the SV-LARI group, a higher change in refractive astigmatism was observed in Phase 2 (-0.12 ± 0.45 D, P = 0.03), but there were no significant differences in changes in refractive J0 and J45, corneal astigmatism, corneal J0 and J45 between Phases 1 and 2 (all P > 0.05). Conclusions Wearing LARI lenses for two years did not seem to lead to any clinically significant additional progression in refractive and corneal astigmatism.
Su et al. (Fri,) studied this question.