The study investigated differences in cardiovascular morbidity and mortality between successful strict, failed strict, and lenient rate control, but results were truncated from the abstract.
Observational (n=614)
Does successful strict rate control improve cardiovascular morbidity and mortality compared to lenient rate control in patients with permanent atrial fibrillation?
This secondary analysis of the RACE II study investigates whether achieving strict rate control targets in permanent AF improves outcomes compared to lenient rate control, though results are truncated in the abstract.
Objectives This study sought to investigate differences in outcome between patients treated with successful strict, failed strict, and lenient rate control. Background The RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation) study showed no difference in outcome between lenient and strict rate control in patients with permanent atrial fibrillation (AF). However, in the strict group not all patients achieved the pre-defined heart rate target. Methods The primary outcome was a composite of cardiovascular morbidity and mortality. For the current analysis outcome events were analyzed from end of the dose-adjustment phase until end of follow-up (median 2.9 years interquartile range: 2.4 to 3.0 years). Of 614 patients, 608 completed the dose-adjustment phase-301 in the strict (resting heart rate Original language English Pages (from-to) 741-748 Journal Journal of the American College of Cardiology Volume 61 Issue number 7 DOIs https://doi.org/10.1016/j.jacc.2012.11.038 Publication status Published - 19 Feb 2013 Keywords atrial fibrillation outcome quality of life rate control
“Our study suggests that lenient rate control may be adopted as the first-choice rate control strategy … both for high- and low-risk patients. … If a patient comes into the office with permanent atrial fibrillation, a target resting heart rate just under 110 bpm on a 12-lead ECG is good enough.”
Groenveld et al. (2013) conducted an observational in permanent atrial fibrillation (n=614). Strict rate control (successful and failed) vs. Lenient rate control was evaluated on composite of cardiovascular morbidity and mortality. The study investigated differences in cardiovascular morbidity and mortality between successful strict, failed strict, and lenient rate control, but results were truncated from the abstract.